Targeting TMED4 enhances CD8+ T cell function and CAR T cell efficacy in solid tumors through the IRE1α-autophagy axis
Huizi Wang, Licai Shi, Ke Jiang, Shuyao Wu, Zhenyan Jiang, Yuexiao Tao, Jia Li, Xin Li, Jiamin Liu, Jun Ni, Emily Jiatong Wu, Sophia Jiaxin Wu, Guang Chen, Ming Qin, Lin Xu, Chu-Hu Lai, Alexandra Aic
Journal：Science Advances
IF：13.9
DOI：10.1126/sciadv.aee0517
PMID：
Published：2026-06-12
research field：肿瘤学分子生物学基因治疗细胞生物学免疫学
Abstract
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