Olanzapine (LY170053, LY-170053),又称奥氮平、奥兰氮平或奥兰扎平,是非典型的抗精神病药物,临床上用于控制精神分裂症和双相情感障碍。Olanzapine是一种可口服的5-HT2和D2多巴胺受体拮抗剂,和5-羟色胺能、多巴胺、α1-肾上腺素能和胆碱受体具有纳摩尔的高亲和力。
参考文献
1.Vucicevic L, et al. Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine. Autophagy. 2014;10(12):2362-78.
2.Karpel-Massler G, et al. Olanzapine inhibits proliferation, migration and anchorage-independent growth in human glioblastoma cell lines and enhances temozolomide's antiproliferative effect. J Neurooncol. 2015 Mar;122(1):21-33.
3.Coccurello R, et al. Chronic administration of olanzapine induces metabolic and food intake alterations: a mousemodel of the atypical antipsychotic-associated adverse effects. Psychopharmacology (Berl). 2006 Jul;186(4):561-71.
4.Vieta E. Olanzapine in bipolar disorder. Expert Opin Pharmacother. 2004 Jul;5(7):1613-9.
冰袋运输。粉末直接保存于-20℃,有效期3年。建议分装后-20℃干燥保存,避免反复冻融。