Fingolimod hydrochloride (Fingolimod HCl, FTY720, FTY-720)，又称盐酸芬戈莫德，是有效的1-磷酸鞘氨醇(S1P)的拮抗剂，IC₅₀为0.33 nM，也是S1P受体的激动剂，在复发型多发性硬化症治疗中有重要作用。Fingolimod是鞘氨醇的类似物，可与S1P1、S1P4、S1P5和S1P3受体相互作用，EC₅₀范围介于0.3-3.1 nM之间。

参考文献

1. Rolin J, et al. FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. Cancer Immunol Immunother. 2010 Apr;59(4):575-86.
2. Fransson R, et al. Design, Synthesis, and Anti-leukemic Activity of Stereochemically Defined Constrained Analogs of FTY720 (Gilenya). ACS Med Chem Lett. 2013 Oct 10;4(10):969-973.
3. Cipriani R, et al. FTY720 attenuates excitotoxicity and neuroinflammation. J Neuroinflammation. 2015 May 8;12:86.
4. Coldewey SM, et al. Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis. Sci Rep. 2016 Jun 9;6:27594.

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