Plerixafor (SID791, SID-791, JM3100, JM 3100, AMD 3100, AMD3100)，又称普乐沙福，是一种对称的双环化合物，是CXCR4选择性拮抗剂，IC₅₀为44 nM，可拮抗CXCL12与CXCR4的结合，抑制CXCR4和CXCL12介导的趋化作用，还可以抑制CXCR4介导的HIV感染。Plerixafor也是一种免疫刺激剂，用于体内造血干细胞动员。

参考文献

1.Zabel BA, et al. Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands. J Immunol. 2009 Sep 1;183(5):3204-11.

2.Yang J, et al. Continuous AMD3100 Treatment Worsens Renal Fibrosis through Regulation of Bone Marrow Derived Pro-Angiogenic Cells Homing and T-Cell-Related Inflammation. PLoS One. 2016 Feb 22;11(2):e0149926.

3.Mercurio L, et al. Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model. J Exp Clin Cancer Res. 2016 Mar 25;35:55.

4.Schols D, et al. HIV co-receptor inhibitors as novel class of anti-HIV drugs. Antiviral Res. 2006 Sep;71(2-3):216-26.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。