O-Phospho-L-serine (L-SOP, L-Serine O-phosphate, Dexfosfoserine),也称L-O-磷酸丝氨酸、O-磷酸-L-丝氨酸或磷酸化丝氨酸,是L-serin合成过程中的直接前体物质,是III型代谢型谷氨酸受体(mGluR4, mGluR7, mGluR8)的激动剂,但对I型代谢型谷氨酸受体无亲和力。O-Phospho-L-serine是NMDA竞争性拮抗剂。
参考文献
1.Kang HJ, et al. Determinants of endogenous ligand specificity divergence among metabotropic glutamate receptors. J Biol Chem. 2015 Jan 30;290(5):2870-8.
2.Kang HJ, et al. Selectivity and evolutionary divergence of metabotropic glutamate receptors for endogenous ligands and G proteins coupled to phospholipase C or TRP channels. J Biol Chem. 2014 Oct 24;289(43):29961-74.
3.Bailey TJ, et al. The inhibitor of phagocytosis, O-phospho-L-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina. Exp Eye Res. 2010 Nov;91(5):601-12.
冰袋运输。粉末直接保存于-20℃,有效期3年。建议分装后-20℃干燥保存,避免反复冻融。