KN-62是细胞通透性的CaMKⅡ抑制剂，K_i值为0.9 nM，直接与CAMKII的钙调蛋白结合位点相结合，不能抑制其它类的钙调蛋白敏感激酶，也是P2X7受体拮抗剂。据报道，KN-62在高浓度下能抑制GSK3β、PRAK和MAPKAP-K2。

参考文献

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[2] Wenham RM, Landt M, Walters SM, et, al. Inhibition of insulin secretion by KN-62, a specific inhibitor of the multifunctional Ca2+/calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1992 Nov 30;189(1):128-33. doi: 10.1016/0006-291x(92)91534-w(IF:2.705).

[3] Manosso LM, Moretti M, Ribeiro CM, et, al. Antidepressant-like effect of zinc is dependent on signaling pathways implicated in BDNF modulation. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jun 3;59:59-67. doi: 10.1016/j.pnpbp.2015.01.008(IF:4.315).

-25~-15℃保存，有效期3年。