MK-0752 (MK0752)是可穿过血脑屏障的、可口服的γ-secretase抑制剂，在SH-SY5Y细胞中剂量依赖性减少Aβ40，IC₅₀值为5 nM。

参考文献

[1] Cook JJ, et al., Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound. J Neurosci. 2010 May 12;30(19):6743-50.

[2] Harrison H, et al., Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor. Cancer Res. 2010 Jan 15;70(2):709-18.

冰袋运输。粉末直接保存于-25~-15℃，有效期3年。建议分装后-25~-15℃干燥保存，避免反复冻融。