_{LY2811376是可口服的β位淀粉样蛋白前体蛋白裂解酶1 (BACE1)非肽类抑制剂，IC50值239-249 nM，能抑制过表达APP的HEK293细胞中Aβ的分泌。BACE1是天冬氨酸蛋白酶，是Aβ生成的主要限速酶，在阿尔茨海默病中发挥关键作用。}

参考文献

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-25~-15℃保存，有效期3年。