Amitriptyline (MK-230, N-750, Ro41575, MK230, N750, Ro-41575)，又称阿米替林或阿密替林，为三环类抗抑郁药，是使用最广泛的一种止痛药，镇静作用较强，临床上主要用于治疗焦虑性或激动性抑郁症，可以抑制血清素再摄取转运体(SERT)和去甲肾上腺素再摄取转运体(NET)，K_i为3.45 nM和13.3 nM。

参考文献

[1] S Neil Vaishnavi, et al. Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity. Biol Psychiatry. 2004 Feb 1;55(3):320-2.

[2] Onali P, et al. Direct agonist activity of tricyclic antidepressants at distinct opioid receptor subtypes. J Pharmacol Exp Ther. 2010 Jan;332(1):255-65.

[3] Jang, SW, et al, Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chem Biol. 2009 Jun 26;16(6):644-56.

冰袋运输。粉末直接保存于-25~-15℃，有效期3年。建议溶解分装后于-25~-15℃干燥保存，避免反复冻融。