[ 1 ]Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing

[ 2 ]Bioinspired, Mitochondria-Targeted Single-Atom Nanozyme Enhances Bone Regeneration by Reprogramming Stem Cell Energy Metabolism​

[ 3 ]Time-of-Day Defines the Risk of Thermally Abused Frying Oil to Renal Injury by Modulating the Diurnal Dynamics of Oxylipins

[ 4 ]Control of a sap-sucking insect pest by plastid-mediated RNA interference

[ 5 ]Metformin attenuated sepsis-related liver injury by modulating gut microbiota

[ 6 ]Immuno-Training Remodeled Vascular Microenvironment via Peptide-Functionalized Hydrogel Microspheres for Neural Repair

[ 7 ]Identification of a Bioactive Domain in Type II Collagen That Promotes Bone Repair via EGFR Signaling

[ 8 ]Anti-alcoholism drug disulfiram for targeting glioma energy metabolism using BBB-penetrating delivery of fixed-dose combination

[ 9 ]A non-enzymatic function of neuraminidase 1 restrains hepatic glucagon response in mice

[ 10 ]High-diversity base mutagenesis via simultaneous adenine, cytosine and guanine editing

[ 11 ]Viral Protein-Pseudotyped and siRNA-Electroporated Extracellular Vesicles for Cancer Immunotherapy

[ 12 ]Mesopore Controls the Responses of Blood Clot-Immune Complex via Modulating Fibrin Network

[ 13 ]CeO2 nanohybrid as a synergist for insecticide resistance management

[ 14 ]DNA Framework-Encoded Digital Recorder for Bacterial Discrimination

[ 15 ]In Situ Redox-Omics Decoding of Nanoparticle–Protein Corona Interactions Drives the Mitochondrial Metabolic-Immunological Mechanism in Microglia

[ 16 ]Treg-γδ T cell axis determines sexual dimorphism in hepatocarcinogenesis

[ 17 ]Collaborative Design of MgO/FeOx Nanosheets on Titanium: Combining Therapy with Regeneration

[ 18 ]Targeting metabolic vulnerability in mitochondria conquers MEK inhibitor resistance in KRAS-mutant lung cancer

[ 19 ]Biomimetic Ti–6Al–4V alloy/gelatin methacrylate hybrid scaffold with enhanced osteogenic and angiogenic capabilities for large bone defect restoration

[ 20 ]Enhanced osteogenesis of titanium with nano-Mg(OH)2 film and a mechanism study via whole genome expression analysis

[ 21 ]Chitosan oligosaccharide alleviates and removes the toxicological effects of organophosphorus pesticide chlorpyrifos residues

[ 22 ]SLC2A3-Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

[ 23 ]Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

[ 24 ]Phocaeicola coprophilus-Derived 6-Methyluracil Attenuates Radiation-Induced Intestinal Fibrosis by Suppressing the IDO1-Kynurenine-AHR Axis

[ 25 ]N4-acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

[ 26 ]HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

[ 27 ]Super-Enhancer-Driven SOX4/SMAD3 Mediate Membrane Remodeling by Regulating Phospholipid Metabolism to Accelerate Leukemia Progression

[ 28 ]SATB2 Mediates H3K9 Delactylation by Recruiting HDAC3 to Repress LCN2 and Inhibit Lung Tumor Growth and Metastasis

[ 29 ]Hollow Cu2O Nanozymes Enhance Probiotic Therapy for Colitis via Redox Homeostasis and TXNIP/NLRP3 Inflammasome Inhibition

[ 30 ]Endothelial USP2a-METTL16 loop potentiates IL-6 signaling via m6A-mediated IL-6R stabilization in pulmonary vascular remodeling

[ 31 ]A nitrogen fixing symbiosis-specific pathway required for legume flowering

[ 32 ]Super-enhancer-driven TCF4 orchestrates neuroblastoma metastasis by sphingolipid-dependent membrane remodeling and ITGB1-FAK activation

[ 33 ]Perfluorooctanoic acid (PFOA) exposure affects early embryonic development and offspring oocyte quality via inducing mitochondrial dysfunction

[ 34 ]Carrier-free dual-drug nanoplatforms cooperatively remodel macrophage and VSMC fate specifications for treating abdominal aortic aneurysm

[ 35 ]Postnatal Maxillofacial “Developing” dECM Orchestrates Hierarchical Cross-organ Regeneration via Macrophage Integrin αvβ5-Mediated Efferocytosis-Driven Developmental Recapitulation

[ 36 ]A Native Bioactive Interface Functionalized with Osteoprogenitor Stem Cell-Derived Migrasomes for Enhanced Bone Regeneration

[ 37 ]An epigenetically enhanced whole-cell vaccine in a stimulatory hydrogel for robust antitumor immunity

[ 38 ]Therapeutic translation of traditional Chinese medicine Huangqi derived exosome like nanoparticles: targeting prostate cancer through ferroptosis activation, immune reprogramming, and microbiome modulation

[ 39 ]R-loop processing via REXO4-RNaseH1–mediated endo- and exo-cleavage coupling mode prevents genome instability and antitumor immunity

[ 40 ]An ultrasound-activated PLLA@BaTiO3&SF Janus membrane enhances fracture healing via synergistic piezoelectricity and bioactivity

[ 41 ]EphB4 inhibition defines a druggable synthetic-lethal vulnerability in MYC-driven triple-negative breast cancer

[ 42 ]Loss of RBMS1 promotes anti-tumor immunity through enabling PD-L1 checkpoint blockade in triple-negative breast cancer

[ 43 ]A novel mRNA nanovaccine with dual immunoregulation ameliorates rheumatoid arthritis and associated pneumonia

[ 44 ]A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy

[ 45 ]Targeting Macrophage-to-Myofibroblast Transition Mitigates Progression from Inflammation to Fibrosis in Rosacea

[ 46 ]SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade

[ 47 ]Proteomic analysis reveals ginsenoside Rb1 attenuates myocardial ischemia/reperfusion injury through inhibiting ROS production from mitochondrial complex I

[ 48 ]Magnetism-mediated targeting hyperthermia-immunotherapy in “cold” tumor with CSF1R inhibitor

[ 49 ]A dual functional Ti-Ga alloy: inhibiting biofilm formation and osteoclastogenesis differentiation via disturbing iron metabolism

[ 50 ]Polydisperse polystyrene microplastics exacerbate colitis through gut microbiota-butyrate-PPARγ axis disruption in mice

[ 51 ]Genipin induces liver injury by disrupting the CPS1-regulated urea cycle and redox homeostasis

[ 52 ]System pharmacology reveals the mechanism of Puji Xiaodu Yin against Japanese encephalitis

[ 53 ]Epigenetic activation of the elongator complex sensitizes gallbladder cancer to gemcitabine therapy

[ 54 ]Target-Centric Multiplexed Screening of an Herbal Extract Identifies a Novel Dual A2A/A2B Receptor Antagonist for Cancer Immunotherapy

[ 55 ]Complementary and Synergistic Design of Bi-Layered Double Hydroxides Modified Magnesium Alloy toward Multifunctional Orthopedic Implants

[ 56 ]MRI-guided diagnosis and dual-pathway neuroprotection in ischemic stroke via PDA-engineered apple exosome-like nanoparticles

[ 57 ]Simultaneous epigenetic perturbation and genome imaging reveal distinct roles of H3K9me3 in chromatin architecture and transcription

[ 58 ]Geosmin disrupts energy metabolism and locomotor behavior of zebrafish in early life stages

[ 59 ]MiR-155 knockout alleviates colitis exacerbated by EHDPHP exposure through inhibition of the JAK-STAT-p53 axis and apoptosis

[ 60 ]Physiological and transcriptomic changes of zebrafish (Danio rerio) embryos-larvae in response to 2-MIB exposure

[ 61 ]A tandem activation of NLRP3 inflammasome induced by copper oxide nanoparticles and dissolved copper ion in J774A.1 macrophage

[ 62 ]DcH3.3 and DcNAC1 Regulate the Expression of UGT73A93 Involved in the Changes in Flower Colour and Fungal Resistance in Carnation

[ 63 ]Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation

[ 64 ]Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy

[ 65 ]Transcutaneous allicin oleogel restores energy homeostasis for obesity treatment

[ 66 ]CCS facilitates the progression of ovarian cancer by suppressing ferroptotic cell death via the modulation of p53-mediated expression of SLC7A11 and GPX4

[ 67 ]“Gingival Soft Tissue Integrative” Lithium Disilicate Glass-Ceramics with High Mechanical Properties and Sustained-Release Lithium Ions

[ 68 ]CRISPR-Cas9-based genome-wide screening identified novel targets for treating sorafenib-resistant hepatocellular carcinoma: a cross-talk between FGF21 and the NRF2 pathway

[ 69 ]Aquaporin 11 alleviates retinal Müller intracellular edema through water efflux in diabetic retinopathy

[ 70 ]Metabolomic and transcriptomic analyses of the anti-rheumatoid arthritis potential of xylopic acid in a bioinspired lipoprotein nanoformulation

[ 71 ]Intraocular delivery of ZIF-90-RhB-GW2580 nanoparticles prevents the progression of photoreceptor degeneration

[ 72 ]Toxicity of perfluorobutanesulfonate on gill functions of marine medaka (Oryzias melastigma): A time course and hypoxia co-exposure study

[ 73 ]ZC3H15 promotes glioblastoma progression through regulating EGFR stability

[ 74 ]Malic enzyme 1 contributes to tumorigenesis and lenvatinib resistance in hepatocellular carcinoma via FSP1-dependent ferroptosis evasion

[ 75 ]M2 macrophages promote lymphatic metastasis by regulating PKM2 nuclear translocation in triple-negative breast cancer

[ 76 ]Zinc-Containing Bioactive Glass Programs Macrophage Polarization through Extracellular Traps Regulation for Enhanced Diabetic Wound Healing

[ 77 ]Squalene epoxidase promotes hepatocellular carcinoma development by activating STRAP transcription and TGF-β/SMAD signalling

[ 78 ]Chronic exposure to the star polycation (SPc) nanocarrier in the larval stage adversely impairs life history traits in Drosophila melanogaster

[ 79 ]The sustained PGE2 release matrix improves neovascularization and skeletal muscle regeneration in a hindlimb ischemia model

[ 80 ]Bulk and single-cell transcriptome profiling reveal extracellular matrix mechanical regulation of lipid metabolism reprograming through YAP/TEAD4/ACADL axis in hepatocellular carcinoma

[ 81 ]Recombinant cell-penetrating trichosanthin synergizes anti-PD-1 therapy in colorectal tumor

[ 82 ]Nitrate transporter NRT1.1 and anion channel SLAH3 form a functional unit to regulate nitrate-dependent alleviation of ammonium toxicity

[ 83 ]NDRG2 orchestrates circadian clock stability to suppress tumorigenesis and potentiate oxaliplatin response in colorectal cancer

[ 84 ]Deubiquitinase OTULIN dampens RIG-I-dependent antiviral signaling by removing linear ubiquitination from TRAF6

[ 85 ]The CXCL10/CXCR3 Axis Promotes Disease Pathogenesis in Mice upon CVA2 Infection

[ 86 ]Nitrospira-Driven partial Denitrification: Kinetics, Mechanisms, and synergistic potential with anammox

[ 87 ]Lactate Induces Production of the tRNAHis Half to Promote B-lymphoblastic Cell Proliferation

[ 88 ]Lower fluidity of supported lipid bilayers promotes neuronal differentiation of neural stem cells by enhancing focal adhesion formation

[ 89 ]Exploring the function of stromal cells in cholangiocarcinoma by three-dimensional bioprinting immune microenvironment model.

[ 90 ]Lnc90386 Sponges miR-33-5p to Mediate Mycoplasma gallisepticum-Induced Inflammation and Apoptosis in Chickens via the JNK Pathway

[ 91 ]Delamanid suppresses CXCL10 expression via regulation of JAK/STAT1 signaling and correlates with reduced inflammation in tuberculosis patients

[ 92 ]Construction and Validation of an Epigenetic Regulator Signature as A Novel Biomarker For Prognosis, Immunotherapy, And Chemotherapy In Hepatocellular Carcinoma

[ 93 ]A novel tumor mutational burden-based risk model predicts prognosis and correlates with immune infiltration in ovarian cancer

[ 94 ]Metformin Mitigates Sepsis-Related Neuroinflammation via Modulating Gut Microbiota and Metabolites

[ 95 ]Combination of resolvin E1 and lipoxin A4 promotes the resolution of pulpitis by inhibiting NF-κB activation through upregulating sirtuin 7 in dental pulp fibroblasts

[ 96 ]Osteogenesis, angiogenesis and immune response of Mg-Al layered double hydroxide coating on pure Mg

[ 97 ]Structural characterization and anti-osteoporotic effect of two β-glucan-like polysaccharides from Pinellia ternata

[ 98 ]Low light intensity elongates period and defers peak time of photosynthesis: a computational approach to circadian-clock-controlled photosynthesis in tomato

[ 99 ]LXR activation potentiates sorafenib sensitivity in HCC by activating microRNA-378a transcription

[ 100 ]A paradigm shift in diabetic wound care: Multifunctional silk fibroin-glycidyl methacrylate hydrogels delivering stem cell and immune cell secretome