Apatinib mesylate (YN968D1, Rivoceranib)，又称甲磺酸阿帕替尼或艾坦，是一种可口服的VEGF2抑制剂，IC₅₀值分别为1 nM，阻断VEGF2下游信号传导，具有潜在的抗血管生成和抗肿瘤活性，临床是用于治疗转移性胃癌。

参考文献

1.Tian S, et al, et al. YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo. Cancer Sci. 2011 Jul;102(7):1374-80.

2.Mi YJ, et al. Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters. Cancer Res. 2010 Oct 15;70(20):7981-91.

3.Tong XZ, et al. Apatinib (YN968D1) enhances the efficacy of conventional chemotherapeutical drugs in side population cells and ABCB1-overexpressing leukemia cells. Biochem Pharmacol. 2012 Mar 1;83(5):586-97.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。