Belnacasan (VX-765, VX765)是VRT-043198的口服生物活性前药，一般被代谢为活性分子VRT-043198，是caspase-1选择性抑制剂，Ki值为0.8 nM。Caspase-1活化关键的炎性介质IL-1β，使其转换为有活性的分泌蛋白。Belnacasan可用于研究自身性炎症疾病，目前处于治疗银屑病和癫痫的II期临床试验中。

参考文献

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粉末2~4℃避光保存，有效期3年。