CIL56 (CIL-56, CA3, CA-3)是一种有效的选择性ferroptosis诱导剂，通过增加铁依赖性ROS诱导铁死亡。CIL56还能抑制YAP1/Tead转录活性，对YAP1高表达食管腺癌表现出抗癌活性。此外，CIL56可以通过脂质合成限速酶ACC1触发细胞死亡。

参考文献

1.Shimada K, et al. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat Chem Biol. 2016 Jul;12(7):497-503.

2.Dixon SJ, et al. Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death. ACS Chem Biol. 2015 Jul 17;10(7):1604-9.

3.Song S, et al. A Novel YAP1 Inhibitor Targets CSC-Enriched Radiation-Resistant Cells and Exerts Strong Antitumor Activity in Esophageal Adenocarcinoma. Mol Cancer Ther. 2018 Feb;17(2):443-454.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。