Indirubin (NSC 105327, NSC105327, Couroupitine B, Indigo red, Indigopurpurin)，又称靛玉红，是双吲哚类生物碱，体内毒性低，具有抗炎和抗癌活性，临床上用于慢性粒细胞白血病、异常骨髓增生症及嗜酸性粒细胞增多症治疗。Indirubin是一种有效的CDK和GSK-3β抑制剂，IC₅₀约为5 μM和0.6 μM。

参考文献

1. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276(1): 251-260.
2. Hsieh WL, et al. Indirubin, an acting component of indigo naturalis, inhibits EGFR activation and EGF-induced CDC25B gene expression in epidermal keratinocytes. J Dermatol Sci. 2012 Aug;67(2):140-6.
3. Zhang X, et al. Indirubin inhibits tumor growth by antitumor angiogenesis via blocking VEGFR2-mediated JAK/STAT3 signaling in endothelial cell. Int J Cancer. 2011 Nov 15;129(10):2502-11.
4. Alex D, et al. Indirubin shows anti-angiogenic activity in an in vivo zebrafish model and an in vitro HUVEC model. J Ethnopharmacol. 2010 Sep 15;131(2):242-7.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。