5-Iodo-indirubin-3'-monoxime是一种高效的GSK-3β抑制剂，其IC₅₀值为9 nM。据文献报道，5-Iodo-indirubin-3'-monoxime可上调HASMC细胞中sPLA2-IIA的表达水平，也可改善肥厚心肌的缺血/再灌注损伤。 

参考文献

[1]. Menschikowski M, et al. Glycogen synthase kinase-3beta negatively regulates group IIA phospholipase A2 expression in human aortic smooth muscle and HepG2 hepatoma cells. FEBS Lett. 2004 Nov 5;577(1-2):81-6.

[2]. Barillas R, et al. Inhibition of glycogen synthase kinase-3beta improves tolerance to ischemia in hypertrophied hearts. Ann Thorac Surg. 2007 Jul;84(1):126-33.

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃避光保存，避免反复冻融。