GDC-0068是一种ATP竞争型的高效选择性的PAN-AKT抑制剂，其抑制Akt 1/2/3的IC50值分别是5 nM、18 nM、8 nM。

参考文献

[1]. Lin J, et al. Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models. Clin Cancer Res. 2013 Apr 1;19(7):1760-72.

[2]. Blake JF, et al. Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors. J Med Chem. 2012 Sep 27;55(18):8110-27.

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