LDN193189（DM-3189）是一种高效选择性的BMP（转录活性形态发生蛋白）信号通路抑制剂，抑制BMP I型受体ALK2（活化素受体样激酶-2）和ALK3（活化素受体样激酶-3）的转录活性，其IC50值分别为5 nM和30 nM。

参考文献

[1]. Yu P B, et al. BMP type I receptor inhibition reduces heterotopic ossification[J]. Nature Medicine, 2008, 14(12):1363-1369.

[2]. Ranadive I, et al. Evaluation of multikinase inhibitor LDN193189 induced hepatotoxicity in teleost fish Poecilia latipinna[J]. Drug & Chemical Toxicology, 2018:1.

[3]. Cannon JE, et al. Intersegmental vessel formation in zebrafish: requirement for VEGF but not BMP signalling revealed by selective and non-selective BMP antagonists. Br J Pharmacol. 2010 Sep;161(1):140-9.

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃避光保存，避免反复冻融。