BIO-acetoxime (BIA, GSK3 Inhibitor X, 6-Bromoindirubin-3'-acetoxime)是一种有效的、选择性的GSK3α/β双重抑制剂（IC₅₀值均为10 nM），选择性比CDK5、CDK2和 CDK1高240倍以上。BIO-acetoxime可促进Wnt信号传导，还有抗感染和抗惊厥的作用。

参考文献

[1]. Hsu MJ, Hung SL. Antiherpetic potential of 6-bromoindirubin-3'-acetoxime (BIO-acetoxime) in human oral epithelial cells. Arch Virol. 2013 Jun;158(6):1287-96.

[2]. Aourz N, et al. Identification of GSK-3 as a Potential Therapeutic Entry Point for Epilepsy. ACS Chem Neurosci. 2019 Apr 17;10(4):1992-2003.

[3]. Hsu MJ, et al. PI3K/Akt signaling mediated apoptosis blockage and viral gene expression in oral epithelial cells during herpes simplex virus infection. Virus Res. 2010 Oct;153(1):36-43. 

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃避光保存，避免反复冻融。