Carboxypeptidase A4 promotes migration and invasion of lung cancer cells, and is closely associated with lymph node metastasis
Feng Zhang, Yuan Zhang, Li-xin Sun, Meng Chen, Yu-liang Ran, Li-chao Sun
Journal：Precision Radiation Oncology
IF：0
DOI：10.1002/pro6.1068
PMID：
Published：2019-06-26
research field：肿瘤学分子生物学细胞生物学生物化学
Abstract
The incidence and mortality rate of lung cancer ranks first among all malignant tumors. Lymph node metastasis is the most common mode of metastasis in lung cancer, and it is also an important indicator for treatment strategies and prognosis. Several studies have shown that the carboxypeptidase family plays important roles in cancer metastasis. In the present study, we investigated the effect of carboxypeptidase A4 (CPA4) on human lung cancer cells, and the clinical significance of its levels in lung cancer tissues and corresponding lymph node metastasis tissues.
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