LHX2 Enhances the Malignant Phenotype of Esophageal Squamous Cell Carcinoma by Upregulating the Expression of SERPINE2
Xukun Li, Xueling Wu, Hongyan Chen, Zhihua Liu, Huan He, Luhua Wang
Journal：Genes
IF：4.14
DOI：10.3390/genes13081457
PMID：36011368
Published：2022-08-16
research field：医学细胞生物学生物化学
Abstract
LHX2 dysregulations have been found to present in cancers, but the function of LHX2 in esophageal squamous cell carcinoma (ESCC) remains unknown. Here, we report thatLHX2was upregulated in ESCC tissues in comparison to theLHX2levels in adjacent normal tissues. Loss- and gain-of-function experiments demonstrated that the knockdown of LHX2 markedly inhibited ESCC cells’ proliferation, migration, invasion, tumor growth and metastasis, whereas the overexpression of LHX2 had the opposite effects. A mechanistic investigation revealed that LHX2 bound to the promoter ofSERPINE2gene and transcriptionally regulated the expression of SERPINE2. Collectively, LHX2 facilitates ESCC tumor progression, and it could be a potential therapeutic target for ESCC.Keywords:ESCC;LHX2;oncogene;tumor progression;SERPINE2
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