The N6-methyladenosine reader protein YTHDC2 promotes gastric cancer progression via enhancing YAP mRNA translation
Wei Yuan, Shiqiang Chen, Bo Li, Xiaoyu Han, Bo Meng, Yongping Zou, Shunwu Chang
Journal：Translational Oncology
IF：4.24
DOI：10.1016/j.tranon.2021.101308
PMID：
Published：2021-12-12
research field：肿瘤学分子生物学转化医学癌症生物学心血管生物学
Abstract
Highlights • YTHDC2 is significantly upregulated in human GC tissues, which is linked to poor prognosis.• Knockout of YTHDC2 inhibits GC cell proliferation, migration and invasion.• YTHDC2 enhances YAP translation in a m6A-dependent manner.• YAP transcriptionally activates YTHDC2.• Knockout of YTHDC2 inhibits GC tumor growth and metastasis in vivo.
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