Altered Matrix Metalloproteinases Expression in Placenta from Patients with Gestational Diabetes Mellitus
Rong Ding, Xi-Mei Liu, Yu-Qian Xiang, Yong Zhang, Jun-Yu Zhang, Fei Guo, Zhi-Wei Liu, Jian-Xia Fan
Journal:CHINESE MEDICAL JOURNAL
IF:1.6
DOI:10.4103/0366-6999.231530
PMID:
Published:2018-05-20
research field:分子生物学内分泌学细胞生物学结构生物学遗传学与基因组学妇产科学
Abstract
To the Editor: Gestational diabetes mellitus (GDM) is defined as glucose intolerance with the onset of pregnancy and is related to increased maternal and fetal risks. Incidence of GDM varies in different countries and the prevalence ranges between 4% and 17%.[1] GDM is one of the most common medical complications of pregnancy, negatively affecting fetal development and metabolic balance. If untreated, GDM can cause fetal malformation, macrosomia, fetal growth retardation, and even intrauterine fetal death. Recent studies have shown correlations between GDM and postpartum insulin resistance, pregnancy‐induced hypertension, and dyslipidemia. GDM has also been shown to be associated with placental abnormalities including altered placental function, oxidative stress, and vascular dysfunction.
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