Amsacrine hydrochloride是一种抗肿瘤药物,它通过嵌入DNA并抑制拓扑异构酶II发挥作用。
|
英文别名 (English Synonym) |
Amsacrine hydrochloride |
|
中文名称 (Chinese Name) |
盐酸安吖啶；盐酸胺苯吖啶 |
|
靶点 (Target) |
Topoisomerase |
|
通路 (Pathway) |
Cell Cycle/DNA Damage |
|
CAS号 (CAS NO.) |
54301-15-4 |
|
分子式 (Formula) |
C21H20ClN3O3S |
|
分子量 (Molecular Weight) |
429.92 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Thomas D, Hammerling BC, Wu K, Wimmer AB, Ficker EK, Kirsch GE, Kochan MC, Wible BA, Scholz EP, Zitron E, Kathöfer S, Kreye VA, Katus HA, Schoels W, Karle CA, Kiehn J. Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action. Br J Pharmacol. 2004 Jun,142(3):485-94. doi: 10.1038/sj.bjp.0705795. Epub 2004 May 17. PMID: 15148258, PMCID: PMC1574964.[2]Attia SM. Molecular cytogenetic evaluation of the mechanism of genotoxic potential of amsacrine and nocodazole in mouse bone marrow cells. J Appl Toxicol. 2013 Jun,33(6):426-33. doi: 10.1002/jat.1753. Epub 2011 Nov 11. PMID: 22081495.
