Thiostrepton作为一种抗生素类物质，能够特异性抑制转录因子FOXM1的活性。FOXM1可与YAP/TEAD蛋白复合体发生相互作用，三者形成的YAP/TEAD/FOXM1复合物通过结合于细胞周期相关基因的调控区域，进而对细胞增殖过程产生重要调控作用。
| 英文别名 (English Synonym) | Thiostrepton |
| 中文名称 (Chinese Name) | 硫链丝菌素 |
| 靶点 (Target) | DNA Synthesis |
| 通路 (Pathway) | Cell Cycle/DNA Damage |
| CAS号 (CAS NO.) | 1393-48-2 |
| 分子式 (Formula) | C72H85N19O18S5 |
| 分子量 (Molecular Weight) | 1664.89 |
2~8℃保存，有效期3年。
[1] Zhang X, Cheng L, Minn K, Madan R, Godwin AK, Shridhar V, Chien J. Targeting of mutant p53-induced FoxM1 with thiostrepton induces cytotoxicity and enhances carboplatin sensitivity in cancer cells. Oncotarget. 2014 Nov 30;5(22):11365-80. doi: 10.18632/oncotarget.2497. PMID: 25426548; PMCID: PMC4294351. [2] Sengupta A, Rahman M, Mateo-Lozano S, Tirado OM, Notario V. The dual inhibitory effect of thiostrepton on FoxM1 and EWS/FLI1 provides a novel therapeutic option for Ewing's sarcoma. Int J Oncol. 2013 Sep;43(3):803-12. doi: 10.3892/ijo.2013.2016. Epub 2013 Jul 12. PMID: 23857410; PMCID: PMC3787886.
