Amsacrine
产品介绍
安吖啶是一种具有双重作用机制的抗肿瘤药物：它既能作为DNA嵌入剂与DNA结合，又可有效抑制拓扑异构酶II的活性，从而发挥抗肿瘤效应。
产品性质
产品特色
| 英文别名 (English Synonym) | Amsacrine |
| 中文名称 (Chinese Name) | 安吖啶 |
| 靶点 (Target) | Topoisomerase |
| 通路 (Pathway) | Cell Cycle/DNA Damage |
| CAS号 (CAS NO.) | 51264-14-3 |
| 分子式 (Formula) | C21H19N3O3S |
| 分子量 (Molecular Weight) | 393.46 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
存储条件
-25~-15℃保存，有效期3年
COA
已发表文献
[1] Thomas D, Hammerling BC, Wu K, Wimmer AB, Ficker EK, Kirsch GE, Kochan MC, Wible BA, Scholz EP, Zitron E, Kathöfer S, Kreye VA, Katus HA, Schoels W, Karle CA, Kiehn J. Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action. Br J Pharmacol. 2004 Jun;142(3):485-94. doi: 10.1038/sj.bjp.0705795. Epub 2004 May 17. PMID: 15148258; PMCID: PMC1574964.[2]Attia SM. Molecular cytogenetic evaluation of the mechanism of genotoxic potential of amsacrine and nocodazole in mouse bone marrow cells. J Appl Toxicol. 2013 Jun;33(6):426-33. doi: 10.1002/jat.1753. Epub 2011 Nov 11. PMID: 22081495.
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