Cytarabine hydrochloride作为一种核苷类似物，能够诱导细胞周期停滞于S期并通过抑制DNA聚合酶活性阻断DNA生物合成，其半数抑制浓度（IC50）为16纳摩尔。该化合物同时表现出抗疱疹病毒的活性。
|
英文别名 (English Synonym) |
Cytarabine hydrochloride |
|
中文名称 (Chinese Name) |
盐酸阿糖胞苷 |
|
靶点 (Target) |
DNA Synthesis |
|
通路 (Pathway) |
Cell Cycle/DNA Damage |
|
CAS号 (CAS NO.) |
69-74-9 |
|
分子式 (Formula) |
C9H14ClN3O5 |
|
分子量 (Molecular Weight) |
279.68 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Tobias SC, Borch RF. Synthesis and biological evaluation of a cytarabine phosphoramidate prodrug. Mol Pharm. 2004 Mar-Apr;1(2):112-6. doi: 10.1021/mp034019v. PMID: 15832507. [2] Besirli CG, Deckwerth TL, Crowder RJ, Freeman RS, Johnson EM Jr. Cytosine arabinoside rapidly activates Bax-dependent apoptosis and a delayed Bax-independent death pathway in sympathetic neurons. Cell Death Differ. 2003 Sep;10(9):1045-58. doi: 10.1038/sj.cdd.4401259. PMID: 12934079.
