Irinotecan hydrochloride trihydrate是一种拓扑异构酶I抑制剂,可用于结肠癌与直肠癌研究。
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英文别名 (English Synonym) |
Irinotecan HCl Trihydrate |
|
中文名称 (Chinese Name) |
盐酸伊立替康三水合物 |
|
靶点 (Target) |
Topoisomerase |
|
通路 (Pathway) |
Cell Cycle/DNA Damage |
|
CAS号 (CAS NO.) |
136572-09-3 |
|
分子式 (Formula) |
C33H45ClN4O9 |
|
分子量 (Molecular Weight) |
677.18 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Pavillard V, Agostini C, Richard S, Charasson V, Montaudon D, Robert J. Determinants of the cytotoxicity of irinotecan in two human colorectal tumor cell lines. Cancer Chemother Pharmacol. 2002 Apr,49(4):329-35. doi: 10.1007/s00280-001-0416-0. Epub 2002 Jan 30. PMID: 11914913.[2]Morales C, Zurita M, Vaquero J. Antitumoral effect of irinotecan (CPT-11) on an experimental model of malignant neuroectodermal tumor. J Neurooncol. 2002 Feb,56(3):219-26. doi: 10.1023/a:1015014623569. PMID: 12061727.
