GW9662(TIMTEC-BB/SBB-006523) PPARγ拮抗剂|CAS 22978-25-2（54065ES）

GW9662是一种高效、选择性、不可逆的PPARγ拮抗剂(IC₅₀=3.3 nM)，可修饰PPARγ配体结合位点的半胱氨酸残基。同时，GW9662也是一种有效的PPARα拮抗剂(IC₅₀=32 nM)。

参考文献

[1] Seargent JM, et al. GW9662, a potent antagonist of PPARgamma, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARgamma agonist rosiglitazone, independently of PPARgamma activation. Br J Pharmacol. 2004 Dec;143(8):933-7.

[2] Collino M, et al. The selective PPARgamma antagonist GW9662 reverses the protection of LPS in a model of renal ischemia-reperfusion. Kidney Int. 2005 Aug;68(2):529-36.

-25~-15℃保存，有效期3年。