Tozasertib是一种pan-Aurora激酶抑制剂，作用于Aurora A/B/C激酶的K_i值分别为 0.6、18、4.6 nM，具有抗肿瘤活性。

参考文献

[1] Harrington EA, Bebbington D, Moore J, et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat Med. 2004 Mar;10(3):262-7. doi: 10.1038/nm1003(IF:30.641).

[2] Arlot-Bonnemains Y, Baldini E, Martin B, et al. Effects of the Aurora kinase inhibitor VX-680 on anaplastic thyroid cancer-derived cell lines. Endocr Relat Cancer. 2008 Jun;15(2):559-68. doi: 10.1677/ERC-08-0021(IF:4.774).

-25~-15℃保存，有效期3年。