Nordihydroguaiaretic acid是一种天然酚类抗氧化剂，可抑制5-脂氧合酶与酪氨酸激酶活性，并作为胰岛素样生长因子1受体/HER2的细胞毒性抑制剂诱导细胞凋亡；该化合物还能抑制p300、激活自噬、保护细胞免于铁死亡，并具有自由基清除能力。
| 英文别名 (English Synonym) | Nordihydroguaiaretic acid |
| 中文名称 (Chinese Name) | 去甲二氢愈创木酸 |
| 靶点 (Target) | mTOR |
| 通路 (Pathway) | PI3K/Akt/mTOR |
| CAS号 (CAS NO.) | 500-38-9 |
| 分子式 (Formula) | C18H22O4 |
| 分子量 (Molecular Weight) | 302.36 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
-25~-15℃保存，有效期3年
[1] West M, Mhatre M, Ceballos A, Floyd RA, Grammas P, Gabbita SP, Hamdheydari L, Mai T, Mou S, Pye QN, Stewart C, West S, Williamson KS, Zemlan F, Hensley K. The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice. J Neurochem. 2004 Oct;91(1):133-43. doi: 10.1111/j.1471-4159.2004.02700.x. PMID: 15379894.[2]Lu F, Luo G, Qiao L, Jiang L, Li G, Zhang Y. Virtual Screening for Potential Allosteric Inhibitors of Cyclin-Dependent Kinase 2 from Traditional Chinese Medicine. Molecules. 2016 Sep 21;21(9):1259. doi: 10.3390/molecules21091259. PMID: 27657032; PMCID: PMC6274045.[3]Zhang H, Shen WJ, Cortez Y, Kraemer FB, Azhar S. Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPARα-dependent and -independent pathways. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 1;304(1):G72-86. doi: 10.1152/ajpgi.00328.2012. Epub 2012 Oct 25. PMID: 23104557; PMCID: PMC3543637.
