Lobeline hydrochloride作为一种能够透过血脑屏障的烟碱型乙酰胆碱受体激动剂，其作用机制涉及抑制多巴胺在突触小泡的再摄取过程，并通过调节突触前多巴胺储存来促进神经递质释放。研究表明，该化合物在戒烟干预中表现出潜在的治疗价值。
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英文别名 (English Synonym) |
Lobeline hydrochloride |
|
中文名称 (Chinese Name) |
盐酸洛贝林 |
|
靶点 (Target) |
Nicotinic Receptor |
|
通路 (Pathway) |
Neuroscience |
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CAS号 (CAS NO.) |
134-63-4 |
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分子式 (Formula) |
C22H27NO2·HCl |
|
分子量 (Molecular Weight) |
373.92 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Teng L, Crooks PA, Sonsalla PK, Dwoskin LP. Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake. J Pharmacol Exp Ther. 1997 Mar;280(3):1432-44. PMID: 9067333. [2] Harrod SB, Dwoskin LP, Crooks PA, Klebaur JE, Bardo MT. Lobeline attenuates d-methamphetamine self-administration in rats. J Pharmacol Exp Ther. 2001 Jul;298(1):172-9. PMID: 11408539.
