Cimetidine是一种口服有效的组胺类似物，作为可逆性组胺H2受体竞争性拮抗剂，可通过阻断组胺与H2受体的结合发挥胃酸分泌抑制作用，适用于十二指肠溃疡和胃溃疡相关研究；同时该化合物还具备抗癌与抗炎双重活性，其多效性药理特征为相关疾病的机制研究与干预提供了实验基础。
| 英文别名 (English Synonym) | Cimetidine |
| 中文名称 (Chinese Name) | 西咪替丁 |
| 靶点 (Target) | Histamine Receptor |
| 通路 (Pathway) | Neuroscience |
| CAS号 (CAS NO.) | 51481-61-9 |
| 分子式 (Formula) | C10H16N6S |
| 分子量 (Molecular Weight) | 252.34 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
-25~-15℃保存，有效期3年
[1] Sprowl JA, van Doorn L, Hu S, van Gerven L, de Bruijn P, Li L, Gibson AA, Mathijssen RH, Sparreboom A. Conjunctive therapy of cisplatin with the OCT2 inhibitor cimetidine: influence on antitumor efficacy and systemic clearance. Clin Pharmacol Ther. 2013 Nov;94(5):585-92. doi: 10.1038/clpt.2013.145. Epub 2013 Jul 17. PMID: 23863876; PMCID: PMC3832209.[2]Zheng Y, Xu M, Li X, Jia J, Fan K, Lai G. Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells. Mol Immunol. 2013 May;54(1):74-83. doi: 10.1016/j.molimm.2012.10.035. Epub 2012 Dec 5. PMID: 23220070.[3]Fukuda M, Kusama K, Sakashita H. Cimetidine inhibits salivary gland tumor cell adhesion to neural cells and induces apoptosis by blocking NCAM expression. BMC Cancer. 2008 Dec 18;8:376. doi: 10.1186/1471-2407-8-376. PMID: 19091137; PMCID: PMC2635382.[4]Longhini R, Aparecida de Oliveira P, Sasso-Cerri E, Cerri PS. Cimetidine reduces alveolar bone loss in induced periodontitis in rat molars. J Periodontol. 2014 Aug;85(8):1115-25. doi: 10.1902/jop.2013.130453. Epub 2013 Nov 28. PMID: 24283656.
