马来酸美吡拉敏是一种经典的第一代抗组胺药，作为高选择性组胺H1受体拮抗剂，其对H1、H2和H3受体的解离常数（Kd）分别为0.8 nM、5200 nM和>3000 nM，对H1受体的pKd值为9.4，显示出对H1亚型极高的选择性。
|
英文别名 (English Synonym) |
Mepyramine maleate |
|
中文名称 (Chinese Name) |
吡拉明马来酸盐 |
|
靶点 (Target) |
Histamine Receptor |
|
通路 (Pathway) |
Neuroscience |
|
CAS号 (CAS NO.) |
59-33-6 |
|
分子式 (Formula) |
C17H23N3O·C4H4O4 |
|
分子量 (Molecular Weight) |
401.46 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Hill SJ. Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol Rev. 1990 Mar;42(1):45-83. PMID: 2164693.[2]Mojtahedin A, Tamaddonfard E, Zanbouri A. Effects of mepyramine and famotidine on the physostigmine-induced antinociception in the formalin test in rats. Pak J Biol Sci. 2008 Nov 15;11(22):2573-8. doi: 10.3923/pjbs.2008.2573.2578. PMID: 19260335.
