乌美溴铵是一种毒蕈碱受体（mAChR）拮抗剂，对克隆人M1-M5受体亚型均具有高度亲和力，其平衡解离常数（Ki）在0.05至0.16 nM之间。
|
英文别名 (English Synonym) |
Umeclidinium bromide |
|
中文名称 (Chinese Name) |
芜地溴铵 |
|
靶点 (Target) |
Muscarinic Receptor |
|
通路 (Pathway) |
Neuroscience |
|
CAS号 (CAS NO.) |
869113-09-7 |
|
分子式 (Formula) |
C29H34BrNO2 |
|
分子量 (Molecular Weight) |
508.49 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Salmon M, Luttmann MA, Foley JJ, et al. Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases. J Pharmacol Exp Ther. 2013 May;345(2):260-70. PMID: 23435542.[2]Salmon M, Luttmann MA, Foley JJ, Buckley PT, Schmidt DB, Burman M, Webb EF, DeHaas CJ, Kotzer CJ, Barrett VJ, Slack RJ, Sarau HM, Palovich MR, Lainé DI, Hay DW, Rumsey WL. Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases. J Pharmacol Exp Ther. 2013 May;345(2):260-70. doi: 10.1124/jpet.112.202051. Epub 2013 Feb 22. PMID: 23435542.
