扎托洛芬（CN100）是一种口服有效的非甾体抗炎药，作为优先的COX-2抑制剂（对COX-2和COX-1的IC50值分别为0.34 μM和1.3 μM），具有强效的抗炎和镇痛活性，尤其适用于炎性疼痛。
|
英文别名 (English Synonym) |
Zaltoprofen |
|
中文名称 (Chinese Name) |
扎托布洛芬 |
|
靶点 (Target) |
COX |
|
通路 (Pathway) |
Neuroscience |
|
CAS号 (CAS NO.) |
74711-43-6 |
|
分子式 (Formula) |
C17H14O3S |
|
分子量 (Molecular Weight) |
298.36 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Kawai S, Nishida S, Kato M, Furumaya Y, Okamoto R, Koshino T, Mizushima Y. Comparison of cyclooxygenase-1 and -2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human platelets and synovial cells. Eur J Pharmacol. 1998 Apr 17;347(1):87-94. doi: 10.1016/s0014-2999(98)00078-8. PMID: 9650852.[2]Hirate K, Uchida A, Ogawa Y, Arai T, Yoda K. Zaltoprofen, a non-steroidal anti-inflammatory drug, inhibits bradykinin-induced pain responses without blocking bradykinin receptors. Neurosci Res. 2006 Apr;54(4):288-94. doi: 10.1016/j.neures.2005.12.016. Epub 2006 Feb 13. PMID: 16473424.
