苯佐卡因是电压门控钠离子通道（NaV）的孔道阻滞剂，其在+30 mV测试电位下对NaV通道的半数抑制浓度（IC50）为0.8 mM。
|
英文别名 (English Synonym) |
Benzocaine |
|
中文名称 (Chinese Name) |
苯佐卡因 |
|
靶点 (Target) |
Sodium Channel |
|
通路 (Pathway) |
Membrane Transporter/Ion Channel |
|
CAS号 (CAS NO.) |
94-09-7 |
|
分子式 (Formula) |
C9H11NO2 |
|
分子量 (Molecular Weight) |
165.19 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Wang GK, Quan C, Wang S. A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels. Pflugers Arch. 1998 Jan;435(2):293-302. doi: 10.1007/s004240050515. PMID: 9382945.[2]Di Croce D, Trinks PW, Grifo MB, Takara D, Sánchez GA. Drug action of benzocaine on the sarcoplasmic reticulum Ca-ATPase from fast-twitch skeletal muscle. Naunyn Schmiedebergs Arch Pharmacol. 2015 Nov;388(11):1163-70. doi: 10.1007/s00210-015-1149-7. Epub 2015 Jul 15. PMID: 26173386.
