丙磺舒是一种有效的选择性瞬时受体电位香草酸受体2（TRPV2）激动剂，同时还能抑制pannexin 1通道。
|
英文别名 (English Synonym) |
Probenecid |
|
中文名称 (Chinese Name) |
丙磺舒 |
|
靶点 (Target) |
TRPV |
|
通路 (Pathway) |
Membrane Transporter/Ion Channel |
|
CAS号 (CAS NO.) |
57-66-9 |
|
分子式 (Formula) |
C13H19NO4S |
|
分子量 (Molecular Weight) |
285.36 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Bakos E, Evers R, Sinkó E, Váradi A, Borst P, Sarkadi B. Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57(4):760-8. doi: 10.1124/mol.57.4.760. PMID: 10727523.[2]Koch SE, Gao X, Haar L, Jiang M, Lasko VM, Robbins N, Cai W, Brokamp C, Varma P, Tranter M, Liu Y, Ren X, Lorenz JN, Wang HS, Jones WK, Rubinstein J. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. J Mol Cell Cardiol. 2012 Jul;53(1):134-44. doi: 10.1016/j.yjmcc.2012.04.011. Epub 2012 Apr 27. PMID: 22561103; PMCID: PMC3372642.
