Quinidine (15% dihydroquinidine)是一种口服有效的抗心律失常药物，具有多重药理作用：作为细胞色素P450db的选择性抑制剂和钾离子通道阻滞剂（IC50值为19.9微摩尔），该化合物还能诱导细胞凋亡过程，临床上亦可用于疟疾的相关研究。
|
英文别名 (English Synonym) |
Quinidine |
|
中文名称 (Chinese Name) |
奎尼丁；奎宁树 |
|
靶点 (Target) |
Other Channel Modulators |
|
通路 (Pathway) |
Membrane Transporter/Ion Channel |
|
CAS号 (CAS NO.) |
56-54-2 |
|
分子式 (Formula) |
C20H24N2O2 |
|
分子量 (Molecular Weight) |
324.42 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Lee SY, Rhee YH, Jeong SJ, Lee HJ, Lee HJ, Jung MH, Kim SH, Lee EO, Ahn KS, Ahn KS, Kim SH. Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. Environ Toxicol. 2011 Aug;26(4):424-31. doi: 10.1002/tox.20568. Epub 2010 Mar 1. PMID: 20196146. [2] Jamali H, Heydari A. Effect of dextromethorphan/quinidine on pentylenetetrazole- induced clonic and tonic seizure thresholds in mice. Neurosci Lett. 2020 Jun 11;729:134988. doi: 10.1016/j.neulet.2020.134988. Epub 2020 Apr 20. PMID: 32325102.
