Aniracetam (Ro 13-5057)是一种口服活性的神经保护益智剂。它通过增强海马CA1区的iQA反应和Schaffer侧支突触的EPSPs,并预防高碳酸血症模型大鼠的CO₂诱导性学习障碍,用于脑功能障碍研究。
|
英文别名 (English Synonym) |
Aniracetam |
|
中文名称 (Chinese Name) |
茴拉西坦 |
|
靶点 (Target) |
AMPAR |
|
通路 (Pathway) |
Membrane Transporter/Ion Channel |
|
CAS号 (CAS NO.) |
72432-10-1 |
|
分子式 (Formula) |
C12H13NO3 |
|
分子量 (Molecular Weight) |
219.24 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Pizzi M, Fallacara C, Arrighi V, Memo M, Spano PF. Attenuation of excitatory amino acid toxicity by metabotropic glutamate receptor agonists and aniracetam in primary cultures of cerebellar granule cells. J Neurochem. 1993 Aug,61(2):683-9. doi: 10.1111/j.1471-4159.1993.tb02173.x. PMID: 8101561.[2]Cumin R, Bandle EF, Gamzu E, Haefely WE. Effects of the novel compound aniracetam (Ro 13-5057) upon impaired learning and memory in rodents. Psychopharmacology (Berl). 1982,78(2):104-11. doi: 10.1007/BF00432244. PMID: 6817363.
