Ivacaftor（VX-770）是一种具有口服活性的囊性纤维化跨膜传导调节因子（CFTR）增效剂。
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英文别名 (English Synonym) |
Ivacaftor (VX-770) |
|
中文名称 (Chinese Name) |
依伐卡托 |
|
靶点 (Target) |
CFTR |
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通路 (Pathway) |
Membrane Transporter/Ion Channel |
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CAS号 (CAS NO.) |
873054-44-5 |
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分子式 (Formula) |
C24H28N2O3 |
|
分子量 (Molecular Weight) |
392.49 |
|
纯度 (Purity) |
≥98% |
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溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Delaunay JL, Bruneau A, Hoffmann B, Durand-Schneider AM, Barbu V, Jacquemin E, Maurice M, Housset C, Callebaut I, Aït-Slimane T. Functional defect of variants in the adenosine triphosphate-binding sites of ABCB4 and their rescue by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor (VX-770). Hepatology. 2017 Feb;65(2):560-570. doi: 10.1002/hep.28929. Epub 2016 Dec 24. PMID: 28012258. [2] Hadida S, Van Goor F, Zhou J, Arumugam V, McCartney J, Hazlewood A, Decker C, Negulescu P, Grootenhuis PD. Discovery of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator. J Med Chem. 2014 Dec 11;57(23):9776-95. doi: 10.1021/jm5012808. Epub 2014 Dec 2. PMID: 25441013.
