二氮嗪（Sch-6783）是一种ATP敏感性钾通道（KATP）激活剂，通过作用于该通道发挥药理作用，在高胰岛素血症的研究中具有应用潜力。
|
英文别名 (English Synonym) |
Diazoxide |
|
中文名称 (Chinese Name) |
二氮嗪 |
|
靶点 (Target) |
AMPAR |
|
通路 (Pathway) |
Membrane Transporter/Ion Channel |
|
CAS号 (CAS NO.) |
364-98-7 |
|
分子式 (Formula) |
C8H7ClN2O2S |
|
分子量 (Molecular Weight) |
230.67 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Virgili N, Mancera P, Wappenhans B, Sorrosal G, Biber K, Pugliese M, Espinosa-Parrilla JF. K(ATP) channel opener diazoxide prevents neurodegeneration: a new mechanism of action via antioxidative pathway activation. PLoS One. 2013 Sep 11;8(9):e75189. doi: 10.1371/journal.pone.0075189. Erratum in: PLoS One. 2013 Sep 19;8(9). doi: 10.1371/annotation/0e045706-ea24-41db-be90-27d1cbcd35b1. PMID: 24040400; PMCID: PMC3770693.[2]Wu H, Wang P, Li Y, Wu M, Lin J, Huang Z. Diazoxide Attenuates Postresuscitation Brain Injury in a Rat Model of Asphyxial Cardiac Arrest by Opening Mitochondrial ATP-Sensitive Potassium Channels. Biomed Res Int. 2016;2016:1253842. doi: 10.1155/2016/1253842. Epub 2016 Aug 28. PMID: 27648441; PMCID: PMC5018309.
