格列喹酮是一种通过与胰腺β细胞结合促进胰岛素释放以调节血糖的降糖药；新研究发现其还具有抗炎、抗癌和抗氧化等多重药理活性：可抑制小胶质细胞中LPS诱导的ERK/STAT3/NF-κB磷酸化及促炎因子释放，并在肺癌细胞中显示出抗癌潜力，因此可用于2型糖尿病及其并发症、癌症等疾病的研究。
|
英文别名 (English Synonym) |
Gliquidone |
|
中文名称 (Chinese Name) |
格列喹酮 |
|
靶点 (Target) |
Potassium Channel |
|
通路 (Pathway) |
Membrane Transporter/Ion Channel |
|
CAS号 (CAS NO.) |
33342-05-1 |
|
分子式 (Formula) |
C27H33N3O6S |
|
分子量 (Molecular Weight) |
527.63 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Shamona, M., et al. (2024). Vibrational spectra and bioactivity profiling of gliquidone: Integrating experimental and theoretical approaches for antidiabetic, anticancer and antioxidant potential evaluation. Journal of Molecular Liquids, 411, [2]Kim J, Park JH, Shah K, Mitchell SJ, Cho K, Hoe HS. The Anti-diabetic Drug Gliquidone Modulates Lipopolysaccharide-Mediated Microglial Neuroinflammatory Responses by Inhibiting the NLRP3 Inflammasome. Front Aging Neurosci. 2021 Oct 29;13:754123. doi: 10.3389/fnagi.2021.754123. PMID: 34776934; PMCID: PMC8587901.
