呋塞米是一种口服有效的Na+/K+/2Cl-共转运蛋白（NKCC1/NKCC2）抑制剂，也是一种GABAA受体拮抗剂（对含α6亚基受体的选择性是α1亚基的100倍）。作为强效利尿剂，它常用于充血性心力衰竭、高血压和水肿的研究。
|
英文别名 (English Synonym) |
Furosemide |
|
中文名称 (Chinese Name) |
呋塞米 |
|
靶点 (Target) |
NKCC |
|
通路 (Pathway) |
Membrane Transporter/Ion Channel |
|
CAS号 (CAS NO.) |
54-31-9 |
|
分子式 (Formula) |
C12H11ClN2O5S |
|
分子量 (Molecular Weight) |
330.74 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Shiozaki A, Miyazaki H, Niisato N, Nakahari T, Iwasaki Y, Itoi H, Ueda Y, Yamagishi H, Marunaka Y. Furosemide, a blocker of Na+/K+/2Cl- cotransporter, diminishes proliferation of poorly differentiated human gastric cancer cells by affecting G0/G1 state. J Physiol Sci. 2006 Dec;56(6):401-6. doi: 10.2170/physiolsci.RP010806. Epub 2006 Oct 21. PMID: 17052386.[2]Kim SH, Jung G, Kim S, Koo JW. Novel Peptide Vaccine GV1001 Rescues Hearing in Kanamycin/Furosemide-Treated Mice. Front Cell Neurosci. 2018 Jan 19;12:3. doi: 10.3389/fncel.2018.00003. PMID: 29403358; PMCID: PMC5780435.
