Amonafide，又称氨萘非特，是拓扑异构酶II (topoisomerase II)的抑制剂，具有抗肿瘤活性。Amonafide对DNA分子具有较高的亲和力，通过插入DNA抑制Topo II与DNA的结合，从而导致细胞凋亡而不引起DNA裂解。

参考文献

[1] Andersson BS, Beran M, Silberman LE, et al. In vitro toxicity and DNA cleaving capacity of benzisoquinolinedione (nafidimide; NSC 308847) in human leukemia. Cancer Res. 1987 Feb 15;47(4):1040-4(IF:8.378).

[2] Braña MF, Cacho M, García MA, et al. New analogues of amonafide and elinafide, containing aromatic heterocycles: synthesis, antitumor activity, molecular modeling, and DNA binding properties. J Med Chem. 2004 Mar 11;47(6):1391-9. doi: 10.1021/jm0308850(IF:6.054).

-25~-15℃保存，有效期3年。