Camptothecin，又称喜树碱，是从喜树的种子或根皮中提出的一种生物碱，是一种拓扑异构酶I选择性抑制剂，IC₅₀为0.68 μM，有抗肿瘤活性。Camptothecin通过不可逆地与DNA-拓扑异构酶I复合物结合，终止DNA转录和复制，进而抑制细胞周期进程，临床上主要用于治疗白血病、胃癌和肠癌。

参考文献

[1] Luzzio MJ, Besterman JM, Emerson DL, et al. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. J Med Chem. 1995 Feb 3;38(3):395-401. doi: 10.1021/jm00003a001(IF:6.054).

[2] Cheng F, Liu J, Teh C, et al. Camptothecin-induced downregulation of MLL5 contributes to the activation of tumor suppressor p53. Oncogene. 2011 Aug 18;30(33):3599-611. doi: 10.1038/onc.2011.71(IF:6.634).

[3] Schön M, Wienrich BG, Kneitz S, et al. KINK-1, a novel small-molecule inhibitor of IKKbeta, and the susceptibility of melanoma cells to antitumoral treatment. J Natl Cancer Inst. 2008 Jun 18;100(12):862-75. doi: 10.1093/jnci/djn174(IF:10.2110).

-25~-15℃保存，有效期3年。