Vincristine sulfate (Leurocristine sulfate, NSC-67574 sulfate, 22-Oxovincaleukoblastine sulfate, NSC67574 sulfate)，又称硫酸长春新碱、硫酸长春醛碱、长春新碱硫化物或长春新碱硫酸盐，是一种抗肿瘤长春花生物碱，抑制有丝分裂，通过与微管蛋白结合而抑制微管聚合，IC₅₀为32 μM，与microtubule结合的K_i为85 nM，具有广泛的抗肿瘤活性。

参考文献

1.Jordan, M.A., et al. Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res, 1985. 45(6): p. 2741-7.

2.Gidding, C.E., et al, Vincristine revisited. Crit Rev Oncol Hematol, 1999. 29(3): p. 267-87.

3.Donoso, J.A., et al, Action of the vinca alkaloids vincristine, vinblastine, and desacetyl vinblastine amide on axonal fibrillar organelles in vitro. Cancer Res, 1977. 37(5): p. 1401-7.

4.Horton, J.K., et al. Relationships between tumor responsiveness, vincristine pharmacokinetics and arrest of mitosis in human tumor xenografts. Biochem Pharmacol, 1988. 37(20): p. 3995-4000.

5.Baguley, B.C., et al, Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanism. Eur J Cancer, 1991. 27(4): p. 482-7.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。