Ifosfamide，又称异环磷酰胺，是一种氮芥类烷化剂，是环磷酰胺异构体，烷化剂类抗肿瘤药，通过在肝微粒体酶催化下分解释出烷化作用很强的氯乙基磷酰胺来表现细胞毒性，临床上可以用于治疗多种肿瘤，如：恶性淋巴瘤、白血病乳腺癌、宫颈癌等。

参考文献

[1] Chen L, Waxman DJ, Chen D, et al. Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene. Cancer Res. 1996 Mar 15;56(6):1331-40(IF:8.378).

[2] Ribeiro RA, Freitas HC, Freitas HC, et al. Tumor necrosis factor-alpha and interleukin-1beta mediate the production of nitric oxide involved in the pathogenesis of ifosfamide induced hemorrhagic cystitis in mice. J Urol. 2002 May;167(5):2229-34(IF:5.647).

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