A-317491 (A317491)是P2X₃和P2X_2/3受体的非核苷类拮抗剂，K_i值分别为22 nM和9 nM，通过抑制P2X₃受体介导的Ca ²⁺内流减轻神经性和炎性疼痛。P2X₃受体属于嘌呤类受体家族，是非选择性的配体门控离子通道，主要在感觉传入神经元上表达，当被ATP激活后允许Na⁺、K⁺、Ca²⁺通过。

参考文献

[1] Jarvis MF, et, al. A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17179-84.

[2] Wu G, et, al. A-317491, a selective P2X3/P2X2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats. Eur J Pharmacol. 2004 Nov 3;504(1-2):45-53.

冰袋运输。粉末直接保存于-25~-15℃，有效期3年。建议溶解分装后于-25~-15℃干燥保存，避免反复冻融。