Empagliflozin (BI 10773, BI10773)，又称恩格列净，是钠葡萄糖共转运蛋白SGLT2的选择性抑制剂，作用于hSGLT-2的IC₅₀为3.1 nM。Empagliflozin是新型降糖药，通过减少肾脏对葡萄糖重吸收和增加葡萄糖经尿液排泄来降低血糖水平，在临床上用于治疗II型糖尿病。

参考文献

[1] Grempler R, et al. Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors. Diabetes Obes Metab. 2012 Jan;14(1):83-90.

[2] Thomas L, et al. Long-term treatment with empagliflozin, a novel, potent and selective SGLT-2 inhibitor, improves glycaemic control and features of metabolic syndrome in diabetic rats. Diabetes Obes Metab. 2012 Jan;14(1):94-6.

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