Sotagliflozin (LX-4211, LP-802034, LX4211, LP802034)，又称索格列净，是可口服的抗糖尿病药物，SGLT1/SGLT2抑制剂，IC₅₀分别为36 nM和1.8 nM。Sotagliflozin一方面通过抑制SGLT2增加葡萄糖的排出，另一方面通过抑制SGLT1减少经胃肠道入血的葡萄糖，从而有效降低血糖。

参考文献

1.Zambrowicz B, et al. LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial. Clin Pharmacol Ther. 2012 Aug;92(2):158-69.

2.Powell DR, et al. LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1)-mediated absorption of intestinal glucose. J Pharmacol Exp Ther. 2013 May;345(2):250-9.

3.Powell DR, et al. Sotagliflozin improves glycemic control in nonobese diabetes-prone mice with type 1 diabetes. Diabetes Metab Syndr Obes. 2015 Feb 26;8:121-7.

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